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KMID : 0941820000100010019
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Korean Journal of Clinical Pharmacy
2000 Volume.10 No. 1 p.19 ~ p.24
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Effect of Cimetidine on the Pharmacokinetics of Intraveneous Cyclosporine in Human Subjects
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Abstract
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The effect of cimetidine on the pbarmacokinetic parameters of cyclosporine (intravenous administration) were determined in 6 healthy volunteers (22-48 years old, 48-62 kg) by cross-over design. Cyclosporine and cyclosporine metabolites in whole blood were analysed by fluororescence polarization immunoassay (TDx-FLX). The blood concentrations of cyclosporine After pretreatment with cimetidine (200 mg bid, for 3days) were increased significantly at 8-12 hrs compared to the control (p<0.05). The ratios of blood concentrations of cyclosporine metabolites (M1, M17) to parent drug were decreased significantly at 8-12 hrs (p<0.05). Total body clearance (CL) was also decreased significantly (p<0.05), and area under the curve (AUC,%) was increased but not significant.
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